Recent work suggests that DNA replication origins are regulated by the number of multiple mini‐chromosome maintenance (MCM) complexes loaded. Origins are defined by the loading of MCM – the replicative helicase which initiates DNA replication and replication kinetics determined by origin's location and firing times. However, activation of MCM is heterogeneous; different origins firing at different times in different cells. Also, more MCMs are loaded in G1 than are used in S phase. These aspects of MCM biology are explained by (...) the observation that multiple MCMs are loaded at origins. Having more MCMs at early origins makes them more likely to fire, effecting differences in origin efficiency that define replication timing. Nonetheless, multiple MCM loading raises new questions, such as how they are loaded, where these MCMs reside at origins, and how their presence affects replication timing. In this review, we address these questions and discuss future avenues of research. (shrink)

The relationship between ethical ideology and job stress appears to be complex. This study is based on a model presented by Forsyth (Journal of Personality and Social Psychology 39:175, 1980), showing two dimensions (idealism and relativism) that play an important role in ethical evaluation and behavior. Based on a survey of 561 employees of hotel industry in India, ethical ideologies were found to be negatively associated with job stress. The data were analyzed using Pearson correlations and multiple regressions. The result (...) showed that relativism is negatively correlated with job stress. Further, it has been established that idealism and relativism interacted in such a way that there is a negative relationship between idealism and job stress when relativism is low and positive relationship when relativism is high. The findings imply that ethical ideology adversely influences the job stress in the organization. (shrink)

Color conveys critical information about the flavor of food and drink by providing clues as to edibility, flavor identity, and flavor intensity. Despite the fact that more than 100 published papers have investigated the influence of color on flavor perception in humans, surprisingly little research has considered how cognitive and contextual constraints may mediate color–flavor interactions. In this review, we argue that the discrepancies demonstrated in previously-published color–flavor studies may, at least in part, reflect differences in the sensory expectations that (...) different people generate as a result of their prior associative experiences. We propose that color–flavor interactions in flavor perception cannot be understood solely in terms of the principles of multisensory integration but that the role of higher-level cognitive factors, such as expectations, must also be considered. (shrink)

We are living in an algorithmic age where mathematics and computer science are coming together in powerful new ways to influence, shape and guide our behaviour and the governance of our societies. As these algorithmic governance structures proliferate, it is vital that we ensure their effectiveness and legitimacy. That is, we need to ensure that they are an effective means for achieving a legitimate policy goal that are also procedurally fair, open and unbiased. But how can we ensure that algorithmic (...) governance structures are both? This article shares the results of a collective intelligence workshop that addressed exactly this question. The workshop brought together a multidisciplinary group of scholars to consider barriers to legitimate and effective algorithmic governance and the research methods needed to address the nature and impact of specific barriers. An interactive management workshop technique was used to harness the collective intelligence of this multidisciplinary group. This method enabled participants to produce a framework and research agenda for those who are concerned about algorithmic governance. We outline this research agenda below, providing a detailed map of key research themes, questions and methods that our workshop felt ought to be pursued. This builds upon existing work on research agendas for critical algorithm studies in a unique way through the method of collective intelligence. (shrink)

Transcript of discourses recorded in 1991 at Art of Living International Centre, Bangalore, India.

The hidden brain has its finger on the scale when we make all of our most complex and important decisions – it decides who we fall in love with, whether we should convict someone of murder, or which way to run when someone yells “fire ...

The present work, "Indian Philosophers of the Recent Past" , reflects and deliberates over recent Indian scholarship in philosophy. It is to get the present and future generations of philosopher-scholars acquainted with the rich Indian philosophical heritage. This is going to deepen our insights into the nature of philosophical consciousness and into the act of philosophizing. It makes an attempt to analyse the philosophies of outstanding philosophers such as K.C. Bhattacharyya, S. Radhakrishnan, R.D. Ranade, A.C. Mukerji, T.R.V. Murti, N.K. Devraja, (...) J.L. Mehta, J.N. Mohanty, Daya Krishna and S.L. Pandey. The post-Independent Indian philosophy is said to have unique tendencies and trends; some of them can be easily identified as existentialist and phenomenological, idealistic, realistic, humanistic, linguistic and analytico-philosophical comparative philosophy and Indian defence of metaphysics. The volume is unique in its conceptual clarity, lucid expression, systematic presentation and critical exposition of the subject matter. It is undoubtedly a valuable contribution for the seekers of Indian philosophical system which should evoke keen interest among scholars and students of philosophy. (shrink)

This article argues why and how a participatory approach to implement corporate social responsibility (CSR) in a cluster would be beneficial for small- and medium-sized enterprises (SMEs) who are members of the NCE – Subsea cluster in Bergen, Norway. The political and strategic reasons as well as internal motivation for SMEs to incorporate CSR into their business strategies are discussed with support from relevant literature. Furthermore, we offer a discussion on the characteristics of different approaches to incorporating CSR as part (...) of business strategy and provide examples from the Norwegian context. As part of this discussion, we look into some of the clusters in Europe which have adopted a systematic approach to implement CSR as part of their agenda. We propose a means to undertake CSR as part of the cluster through a network model to address the limitations faced by the SMEs when they try to implement CSR individually. A network model (cluster approach) to CSR will motivate the uptake of CSR among SMEs when the network (cluster) is characterized by close geographical proximity and operates in the same sector. The uptake of CSR as part of the network (cluster) agenda can also lead to innovation through cooperation and competition. The particular challenges faced by the SMEs in implementing and sustaining CSR can be also minimized by being part of a network (cluster). (shrink)

The automatic verification of large parts of mathematics has been an aim of many mathematicians from Leibniz to Hilbert. While Gödel's first incompleteness theorem showed that no computer program could automatically prove certain true theorems in mathematics, the advent of electronic computers and sophisticated software means in practice there are many quite effective systems for automated reasoning that can be used for checking mathematical proofs. This book describes the use of a computer program to check the proofs of several celebrated (...) theorems in metamathematics including those of Gödel and Church-Rosser. The computer verification using the Boyer-Moore theorem prover yields precise and rigorous proofs of these difficult theorems. It also demonstrates the range and power of automated proof checking technology. The mechanization of metamathematics itself has important implications for automated reasoning, because metatheorems can be applied as labor-saving devices to simplify proof construction. (shrink)

The present work is a beautific monograph over Kant’s philosophy. It begins with the proper analysis of nature and significance of content copernican revolution. The author has systematically formulated the epistemic and non-epistemic implications of Kant’s Philosophy the epistemic implications cover the philosophical issues and seminal significance: the notion of space and time, the nature and function of categories, distinction of phenomena and noumena, refutation of idealism and Kantain transcendental idealism, transcendental unity of pure apperception, nature function and limitations of (...) reason (vernuft) and few more. The non-epistemic implication encompass: metaphysical, ethical and aesthetic implications. In metaphysical implication the author clearly demonstrated the limit of reason as a theoretical reason can’t venture into the realm of metaphysical(noumenal) entities such as God, Soul and cosmos- leading to reputation of metaphysics. The ethical implication is directed towards ,analysing the nature and good will, holy will and autonomous will, and apart from that a critical treatment is offered to categorical imperative postulated and maxims of morality. The aesthetics implication tries to analyse the content notion of beauty, sublime and teleology of nature. It is on account of the conceptual clarity, linguistic beauty and systematic exposition of the subject matter that book will receive the enthusiastic response from the students and scholars of philosophy. -/- This book is also Peer reviewed in JICPR, Volume XIX, No. 2, April-June, 2002 by Prof. Laksminarayan Lenka, Department of Philosophy, North Eastern Hill University, Shillong. (shrink)

Much previous work has suggested that word order preferences across languages can be explained by the dependency distance minimization constraint (Ferrer‐i Cancho, 2008, 2015; Hawkins, 1994). Consistent with this claim, corpus studies have shown that the average distance between a head (e.g., verb) and its dependent (e.g., noun) tends to be short cross‐linguistically (Ferrer‐i Cancho, 2014; Futrell, Mahowald, & Gibson, 2015; Liu, Xu, & Liang, 2017). This implies that on average languages avoid inefficient or complex structures for simpler structures. But (...) a number of studies in psycholinguistics (Konieczny, 2000; Levy & Keller, 2013; Vasishth, Suckow, Lewis, & Kern, 2010) show that the comprehension system can adapt to the typological properties of a language, for example, verb‐final order, leading to more complex structures, for example, having longer linear distance between a head and its dependent. In this paper, we conduct a corpus study for a group of 38 languages, which were either Subject–Verb–Object (SVO) or Subject–Object–Verb (SOV), in order to investigate the role of word order typology in determining syntactic complexity. We present results aggregated across all dependency types, as well as for specific verbal (objects, indirect objects, and adjuncts) and nonverbal (nominal, adjectival, and adverbial) dependencies. The results suggest that dependency distance in a language is determined by the default word order of a language, and crucially, the direction of a dependency (whether the head precedes the dependent or follows it; e.g., whether the noun precedes the verb or follows it). Particularly we show that in SOV languages (e.g., Hindi, Korean) as well as SVO languages (e.g., English, Spanish), longer linear distance (measured as number of words) between head and dependent arises in structures when they mirror the default word order of the language. In addition to showing results on linear distance, we also investigate the influence of word order typology on hierarchical distance (HD; measured as number of heads between head and dependent). The results for HD are similar to that of linear distance. At the same time, in comparison to linear distance, the influence of adaptability on HD seems less strong. In particular, the results show that most languages tend to avoid greater structural depth. Together, these results show evidence for “limited adaptability” to the default word order preferences in a language. Our results support a large body of work in the processing literature that highlights the importance of linguistic exposure and its interaction with working memory constraints in determining sentence complexity. Our results also point to the possible role of other factors such as the morphological richness of a language and a multifactor account of sentence complexity remains a promising area for future investigation. (shrink)

Sri Aurobindo is one of the most prominent figures in the Indian Philosophy of twentieth century and yet we barely find any mention of his work in the philosophy circles. He has written extensively on metaphysics, aesthetics, and ethics. Sri Aurobindo’s work is all-encompassing and carries marks of a deep yogic insight into both the individual self (with all its parts and their integrated working) and the universe that ultimately shares a relation of identity with the individual in secret. He (...) talks about a world-process that contains evolution qualified with involution. It is one of the most unique features of Sri Aurobindo’s philosophy. He deals with the questions of ignorance also in the most satisfying way. Sri Aurobindo has an integral vision that sees everything in the movement of one and develops the methods and practices of Integral Yoga. In his yogic vision, he not only tries to solve the problems of humanity but also attempts to make a very bold move of transforming the whole earthly existence into a divine existence through one large stride. The epistemological discussion we find in his work is deeply connected with his metaphysics. He articulates the limits and extents of reason and senses and attempts to surpass them. Sri Aurobindo is not an armchair philosopher; he attempts to salvage the human condition by empowering humanity to consciously guide the march of human evolution towards a divine future. The boldness of his vision, the originality of his philosophical work is spectacular. In this paper, I will discuss his World-process, i.e. the evolution qualified with involution. I will also discuss the epistemological foundation of his philosophy, cosmology and integral yoga psychology. For the sake of clarity in understanding, the paper is divided into five major sections starting with an introduction. Integralism is a central idea in Sri Aurobindo’s philosophy and I have tried to do justice with it throughout this paper. In the end, the paper attempts to deals with three main themes—cosmology, integral yoga psychology and integral experience. All these three themes shall bring out—The integral experience of Sri Aurobindo is deeply intertwined with his cosmology and yogic psychology and shall not be seen in isolation. Integral experience of reality is also intertwined and works in tandem with his Integral Yoga. There is a yogic exploration of oneness between the self and world that informs and shapes both his philosophical and yogic endeavors. The rationale behind undertaking this study is to question whether the observations of the physical world from the standpoint of yogic experience could suggest some new theoretical framework for the metaphysical ontology of the world. Taking perspectives from the states of consciousness described by Sri Aurobindo may furnish us with a deeper understanding of the material and metaphysical character of physical categories, such as matter, energy, force, space, and time. This paper however is an introductory overview of Aurobindo’s relevance for cosmology, psychology and integral experience which provides a philosophical framework to reinterpret and arrive at a synthetic metaphysics. (shrink)

Providing people with information is considered an important first step in encouraging them to behave sustainably as it influences their consumption beliefs, attitudes and intentions. However, too much information can also complicate these processes and negatively affect behaviour. This is exacerbated when people have accepted the need to live a more sustainable lifestyle and attempt to enact its principles. Drawing on interview data with people committed to sustainability, we identify the contentious role of knowledge in further disrupting sustainable consumption ideals. (...) Here, knowledge is more than just information; it is familiarity and expertise or how information is acted upon. We find that more knowledge represents a source of dilemma, tension and paralysis. Our data reveal a dark side to people’s knowledge, leading to a ‘self-inflicted sustainable consumption paradox’ in their attempts to lead a sustainable consumption lifestyle. Implications for policy interventions are discussed. (shrink)